Personal history of proliferative breast disease with atypia and risk of multifocal breast cancer. Issue 7 (20th December 2017)

• Record Type: Journal Article
• Authors: Nutter, Ellen L.; Weiss, Julia E.; Marotti, Jonathan D.; Barth, Richard J.; Eliassen, M. Scottie; Goodrich, Martha E.; Petersen, Curtis L.; Onega, Tracy
• Is Part Of: Cancer. Volume 124:Issue 7(2018)
• Page Start: 1350
• Page End: 1357
• Publication Date: 2017-12-20
• Subjects: benign breast disease -- breast cancer risk -- breast neoplasm -- multifocal breast cancer -- proliferative breast disease with atypia; Cancer -- Periodicals; Cancer -- Cytopathology -- Periodicals; 616.99405
• DOI: 10.1002/cncr.31202
• Languages: English
• ISSNs: 0008-543X

Abstract

Abstract : BACKGROUND: A history of proliferative breast disease with atypia (PBDA) may be indicative of an increased risk not just of breast cancer but also of a more aggressive form of breast cancer. METHODS: Multifocal breast cancer (MFBC), defined as 2 or more tumors in the same breast upon a diagnosis of cancer, is associated with a poorer prognosis than unifocal (single‐tumor) breast cancer. PBDA, including atypical ductal hyperplasia and atypical lobular hyperplasia, is a known risk factor for breast cancer. Using New Hampshire Mammography Network data collected for 3567 women diagnosed with incident breast cancer from 2004 to 2014, this study assessed the risk of MFBC associated with a previous diagnosis of PBDA. RESULTS: Women with a history of PBDA were found to be twice as likely to be subsequently diagnosed with MFBC as women with no history of benign breast disease (BBD; odds ratio [OR], 2.23; 95% confidence interval [CI], 1.08‐4.61). Ductal carcinoma in situ on initial biopsy was associated with a 2‐fold increased risk of MFBC in comparison with invasive cancer (OR, 2.13; 95% CI, 1.58‐2.88). BBD and proliferative BBD without atypia were not associated with MFBC. CONCLUSIONS: Women with a history of previous PBDA may be at increased risk for MFBC. Women with a history of PBDA may benefit from additional presurgical clinical workup. Cancer 2018;124:1350‐7 . © 2017 American Cancer Society . Abstract : A history of proliferative breast disease with atypia is indicative of an increased risk of multifocal breast cancer. Women may benefit from additional presurgical clinical workup if they have a history of proliferative breast disease with atypia.