Formation of Water Channels in the Crystalline Hydrates of Macrocyclic Compounds. Issue 13 (8th February 2018)

• Record Type: Journal Article
• Authors: Patil, Rahul S.; Zhang, Chen; Sikligar, Kanishka; Baker, Gary A.; Atwood, Jerry L.
• Is Part Of: Chemistry. Volume 24:Issue 13(2018)
• Page Start: 3299
• Page End: 3304
• Publication Date: 2018-02-08
• Subjects: crystal structures -- macrocycles -- hydrogen bonds -- water channels; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201705609
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: Crystalline hydrates of macrocyclic compounds such as pyroagllol[4]arenes (PgCs) and resorcin[4]arenes (RsCs) are rare owing to their lower water solubility. Functionalization of these macrocyclic compounds is an affordable way to enhance water solubility. However, functionalization also encounters the formation of multiple conformers and subsequent difficulty in purification of the product. Herein, four novel crystalline hydrates of functionalized PgCs and RsCs were synthesized. Formation of water channels and the effects of intermolecular interactions on the physical properties of these novel hydrates are discussed. Abstract : Change the channel : Crystalline hydrates of macrocyclic compounds such as pyroagllol[4]arenes (PgCs) and resorcin[4]arenes (RsCs) are rare owing to their lower water solubility. Herein four novel crystalline hydrates of functionalized PgCs and RsCs were synthesiszed. Formation of water channels and the effects of intermolecular interactions on the physical properties of these novel hydrates are discussed.