Location-specific nanoplasmonic sensing of biomolecular binding to lipid membranes with negative curvature. Issue 37 (9th September 2015)

• Record Type: Journal Article
• Authors: Junesch, Juliane; Emilsson, Gustav; Xiong, Kunli; Kumar, Shailabh; Sannomiya, Takumi; Pace, Hudson; Vörös, Janos; Oh, Sang-Hyun; Bally, Marta; Dahlin, Andreas B.
• Is Part Of: Nanoscale. Volume 7:Issue 37(2015)
• Page Start: 15080
• Page End: 15085
• Publication Date: 2015-09-09
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c5nr04208a
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Location-specific nanoplasmonic sensing by monitoring different spectral parameters is used to show how norovirus accumulate in membrane invaginations. Abstract : The biochemical processes of cell membranes are sensitive to the geometry of the lipid bilayer. We show how plasmonic "nanowells" provide label-free real-time analysis of molecules on membranes with detection of preferential binding at negative curvature. It is demonstrated that norovirus accumulate in invaginations due to multivalent interactions with glycosphingolipids.