Ethnic Disparity in the Incidence and Outcome of Biliary Atresia in New Zealand. Issue 2 (February 2018)

• Record Type: Journal Article
• Authors: Evans, Helen M.; Asher, M. Innes; Cameron-Christie, Sophia; Farthing, Sonja; McCall, John; Robertson, Stephen P.; Wong, Hayley; Morreau, Philip N.
• Is Part Of: Journal of pediatric gastroenterology and nutrition. Volume 66:Issue 2(2018)
• Publication Date: 2018-02
• Subjects: Kasai portoenterostomy -- Māori -- Pacific -- Polynesian; Children -- Nutrition -- Periodicals; Pediatric gastroenterology -- Periodicals; Infants -- Nutrition -- Periodicals; Nutrition disorders in children -- Periodicals; Child Nutrition -- Periodicals; Digestive System -- growth & development -- Periodicals; Gastrointestinal Diseases -- Periodicals; Infant Nutrition -- Periodicals; Nutrition Disorders -- Periodicals; Child; 618.923
• DOI: 10.1097/MPG.0000000000001781
• Languages: English
• ISSNs: 0277-2116

Abstract

Abstract : ABSTRACT: To determine incidence and outcome of biliary atresia (BA) between ethnic groups in New Zealand (NZ), a retrospective review was undertaken of children with BA born between 2002 and 2014. Prioritized ethnicity was used to determine ethnicity and was compared to population data. Uni- and multivariate analyses were undertaken to determine demographic and biochemical factors associated with outcome. Overall incidence was 1 in 9181 (Māori 1 in 5285; European 1 in 16, 228; P < 0.0001). Overall and transplant-free survival rates at 1, 2, and 5 years were 92%, 86%, 82% and 70%, 49%, 30% respectively with Māori having improved transplant-free survival ( P < 0.05) despite European children undergoing Kasai earlier (49 vs 63 days). BA is more common in NZ than Europe and North America, which is attributable to a higher incidence in Māori but overall outcome is poorer. Māori have improved transplant-free survival compared to NZ European children but the reason is unknown.