Adverse effects of a synthetic pyrethroid insecticide cypermethrin on life parameters and antioxidant responses in the marine copepods Paracyclopina nana and Tigriopus japonicus. (February 2019)

• Record Type: Journal Article
• Authors: Zhou, Jiaying; Kang, Hye-Min; Lee, Young Hwan; Jeong, Chang-Bum; Park, Jun Chul; Lee, Jae-Seong
• Is Part Of: Chemosphere. Volume 217(2019)
• Page Start: 383
• Page End: 392
• Publication Date: 2019-02
• Subjects: Cypermethrin -- Insecticide -- Copepod -- Tigriopus japonicus -- Paracyclopina nana -- Antioxidants; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2018.10.217
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: To find the adverse effects induced by cypermethrin, the ecotoxicological model copepods Tigriopus japonicus and Paracyclopina nana were exposed under cypermethrin, which is a widely used type-II pyrethroid insecticide in agriculture. Despite its large-scale application as insecticide in agriculture, little information is available on its adverse effects on aquatic invertebrates. In this study, the toxicity of cypermethrin on two copepods was assessed based on life parameters (growth rate and reproduction), oxidative stress and consequent antioxidant enzymatic activities, and gene expression profiles of antioxidants. The acute toxicity alone demonstrated that P. nana is less tolerant and sensitive against cypermethrin, compared to T. japonicus . However, under chronic exposure, life parameters of both P. nana and T. japonicus were severely affected by cypermethrin. Among antioxidant enzymatic activities, superoxide dismutase (SOD) and glutathione S -transferase (GST), in particular, demonstrated significant increase in response to cypermethrin. Furthermore, temporal-mRNA expression profile showed modulations in antioxidant related genes in response to cypermethrin. Our results provide the underlying toxic mechanism of cypermethrin and the oxidative stress defense mechanism and species-specific tolerance against cypermethrin in two model copepods species. Highlights: The toxicity of cypermethrin was assessed in vivo and in vitro endpoints. T. japonicus was at a higher risk to cypermethrin compared to P. nana. P. nana has well-developed detoxification system under chronic exposure. The underlying toxic mechanism of cypermethrin was revealed in two copepods. GST and SOD are likely useful biomarkers in response to cypermethrin.