(R)-panaxadiol by whole cells of filamentous fungus Absidia coerulea AS 3.3382. Issue 8 (3rd August 2018)

• Record Type: Journal Article
• Authors: Song, Yan; Yan, Sen-Sen; Lin, Hai-Jun; Li, Jian-Lin; Zhai, Xu-Guang; Ren, Jie; Chen, Guang-Tong
• Is Part Of: Journal of Asian natural products research. Volume 20:Issue 8(2018)
• Page Start: 719
• Page End: 726
• Publication Date: 2018-08-03
• Subjects: 20(R)-panaxadiol -- biotransformation -- Absidia coerulea -- anti-hepatic fibrosis; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2017.1358267
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: The microbial transformation of 20( R )-panaxadiol (PD ) by the fungus Absidia coerulea AS 3.3382 afforded three new and three known metabolites. The structures of the metabolites were characterized as 3-oxo-20( R )-panaxadiol (1 ), 3-oxo-7β- hydroxyl-20( R )-panaxadiol (2 ), 3-oxo-22β-hydroxyl-20( R )-panaxadiol (3 ), 3-oxo- 7β, 22β-dihydroxyl-20( R )-panaxadiol (4 ), 3-oxo-7β, 24β-dihydroxyl-20( R )-panaxadiol (5 ), and 3-oxo-7β, 24α-dihydroxyl-20( R )-panaxadiol (6 ). Among them, 2-4 were new compounds. In addition, compounds3 and4 exhibited significant anti-hepatic fibrosis activity. Abstract :