Structure determination of two new C21 steroidal glycosides from Cynanchum komarovii. Issue 9 (2nd September 2018)

• Record Type: Journal Article
• Authors: Zhao, Dan; Tang, Ming-Xu; Su, Shan-Shan; Lu, Xiao-Jie; Wang, Yu-Bo; Chen, Shao-Fei; Wang, Hai-Feng; Chen, Gang; Pei, Yue-Hu
• Is Part Of: Journal of Asian natural products research. Volume 20:Issue 9(2018)
• Page Start: 852
• Page End: 859
• Publication Date: 2018-09-02
• Subjects: Asclepiadaceae -- Cynanchum komarovii -- C21 steroidal glycoside -- komaroside R -- komaroside S; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2017.1396977
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Two new 13, 14:14, 15-disecopregnane-type C21 steroidal glycosides, namely komarosides R (1 ) and S (2 ), along with four known compounds (3 –6 ), were obtained from the 95% ethanol extract of the whole herbs of Cynanchum komarovii Al.Iljinski (Asclepiadaceae). The structures of new compounds were elucidated on the basis of 1D, 2D NMR spectroscopic data and acid hydrolysis. Compounds1 and2 showed potent inhibitory activities against human leukemia cell line (HL-60) with IC50 values being 6.2 and 17.6 μM, respectively, compared to the positive control 5-fluorouracil (6.4 μM). Abstract :