Cytotoxic ring A-seco triterpenoids from the stem bark of Dysoxylum lukii. Issue 9 (2nd September 2018)

• Record Type: Journal Article
• Authors: Huang, Rui; Zhao, Ying; Wang, Ying; Zhou, Lei; Chen, Yu-Feng; Wang, Jin-Feng
• Is Part Of: Journal of Asian natural products research. Volume 20:Issue 9(2018)
• Page Start: 860
• Page End: 866
• Publication Date: 2018-09-02
• Subjects: Dysoxylum lukii -- Meliaceae -- triterpenoids -- cytotoxicity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2017.1399880
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: A chemical investigation of the 70% ethanol extract from the stem bark of Dysoxylum lukii afforded three new ring A-seco triterpenoids, dysoxylukiines A–C (1 –3 ). Their structures were elucidated on the basis of extensive 1D and 2D NMR (COSY, HMQC, HMBC, and NOESY) analyses. The isolated compounds were evaluated in vitro for cytotoxic properties. Consequently, compound3 exhibited modest cytotoxic activities against four osteosarcoma cell lines (SOSP-9607, MG-63, Saos-2, and M663) with IC50 values less than 10 μM. Abstract :