Lanostane triterpenoids and ergostane-type steroids from the cultured mycelia of Ganoderma capense. Issue 9 (2nd September 2018)

• Record Type: Journal Article
• Authors: Tan, Zhen; Zhao, Jin-Lian; Liu, Ji-Mei; Zhang, Min; Chen, Ri-Dao; Xie, Ke-Bo; Chen, Da-Wei; Dai, Jun-Gui
• Is Part Of: Journal of Asian natural products research. Volume 20:Issue 9(2018)
• Page Start: 844
• Page End: 851
• Publication Date: 2018-09-02
• Subjects: Ganoderma capense -- triterpenoids -- steroids -- cytotoxic activity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2017.1399879
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Two new lanostane triterpenoids (1 and2 ), two new ergostane-type steroids (3 and4 ) together with two known lanostane triterpenoids (5 and6 ) and one known steroid (7 ) were isolated from the cultured mycelia of Ganoderma capense (CGMCC 5.71). Their structures were determined on the basis of extensive spectroscopic (HRESIMS, 1D NMR, 2D NMR) data analyses. Compound1 exhibited moderate cytotoxic activity against the human cancer cell line NCI-H1650 with an IC50 value of 22.3 μM, and7 displayed cytotoxic activity against the human cancer cell line HCT116 with an IC50 value of 17.4 μM. In addition, compounds2, 3, 5, and6 displayed weak anti-HIV activity with IC50 values of 23.5, 46.7, 21.6, and 30.1 μM, respectively. Abstract :