New aporphine alkaloids from the aerial parts of Piper semiimmersum§. Issue 8 (3rd August 2018)

• Record Type: Journal Article
• Authors: Zhang, Dong-Dong; Yang, Jun; Luo, Ji-Feng; Li, Xiao-Nian; Long, Chun-Lin; Wang, Yue-Hu
• Is Part Of: Journal of Asian natural products research. Volume 20:Issue 8(2018)
• Page Start: 734
• Page End: 743
• Publication Date: 2018-08-03
• Subjects: Piperaceae -- Piper semiimmersum -- aporphine alkaloids -- antiplatelet aggregation; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2017.1346630
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Two new aporphine alkaloids, semiimmersumines A (1 ) and B (2 ), along with 20 known compounds, were isolated from the aerial parts of Piper semiimmersum (Piperaceae). The structures of the new compounds were elucidated based on the analysis of 1D and 2D NMR, MS, and CD data. The absolute configuration of semiimmersumine A (1 ) was determined by single crystal X-ray diffraction analysis using anomalous dispersion with copper radiation. The effects of all compounds from the plant on rabbit platelet aggregation induced by thrombin (IIa) or PAF were also evaluated. Abstract :