NIR-responsive carbon-based nanocarriers for switchable on/off drug release and synergistic cancer therapy. Issue 47 (6th November 2018)

• Record Type: Journal Article
• Authors: Nie, Rongrong; Liu, Hongji; Hu, Lin; Gu, Xinyu; Qian, Junchao; Wang, Hui
• Is Part Of: Journal of materials chemistry. Volume 6:Issue 47(2018)
• Page Start: 7794
• Page End: 7799
• Publication Date: 2018-11-06
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c8tb02398k
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : This communication reports a chitosan-gated carbon-based nanocarrier as a NIR light-switchable drug delivery system for controlled on/off drug release. Abstract : Herein, we present a light-switchable drug delivery system based on chitosan-gated carbon-based nanocarriers (CGC NCs) that exhibit a loading capacity for doxorubicin as high as ∼89.65 wt% and controlled on/off release with/without NIR irradiation. In vitro and in vivo results show that the CGC NCs manifest high efficacy for cancer therapy through a synergistic effect of combined chemo-photothermal treatment.