Cascade reaction involving Diels–Alder cascade: modular synthesis of amino α-pyrones, indolines and anilines. Issue 24 (22nd November 2018)

• Record Type: Journal Article
• Authors: Shen, Yangyong; Wang, Chaorong; Chen, Wei; Cui, Sunliang
• Is Part Of: Organic chemistry frontiers. Volume 5:Issue 24(2018)
• Page Start: 3574
• Page End: 3578
• Publication Date: 2018-11-22
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c8qo00939b
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A cascade reaction involving Diels–Alder reaction for modular synthesis of amino α-pyrones, indolines and anilines is reported. Abstract : The Diels–Alder reaction is a famous and useful method for the synthesis of six-membered carbocycles and heterocycles, and the investigation to extend its power draws tremendous interests. Herein, we develop a coupling reaction for the modular synthesis of amino α-pyrones as Diels–Alder reaction precursors, and also establish the Diels–Alder cascade for obtaining indolines and anilines. This protocol features readily available starting materials, broad substrate scope and valuable synthetic utility.