A pH-driven ring translocation switch against cancer cells. Issue 98 (21st November 2018)

• Record Type: Journal Article
• Authors: Cheng, Qian; Yin, Hang; Rosas, Roselyne; Gigmes, Didier; Ouari, Olivier; Wang, Ruibing; Kermagoret, Anthony; Bardelang, David
• Is Part Of: Chemical communications. Volume 54:Issue 98(2018)
• Page Start: 13825
• Page End: 13828
• Publication Date: 2018-11-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc08681h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A molecular switch built with cucurbit[7]uril and a 3-station viologen-phenylene-imidazole compound has showed pH actuated ring translocation with high fatigue resistance and promising features against cancer cells. Abstract : A molecular switch built with cucurbit[7]uril and a 3-station viologen-phenylene-imidazole compound exhibited pH actuated ring translocation with high fatigue resistance (up to 10 2 cycles). The switch movement was harnessed toward selectively masking the toxicity of the viologen fragment at neutral pH near non-cancerous cells, while exposing it at acid pH near cancer cells.