Pustular‐type drug‐induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms due to carbamazepine with systemic muscle involvement. Issue 2 (6th December 2012)

• Record Type: Journal Article
• Authors: Matsuda, Haruna; Saito, Kanami; Takayanagi, Yoshikazu; Okazaki, Toshio; Kashima, Kenji; Ishikawa, Kazushi; Kai, Yoshitaka; Takeo, Naoko; Hatano, Yutaka; Okamoto, Osamu; Fujiwara, Sakuhei
• Is Part Of: Journal of dermatology. Volume 40:Issue 2(2013)
• Page Start: 118
• Page End: 122
• Publication Date: 2012-12-06
• Subjects: acute generalized exanthematous pustulosis -- acute generalized pustular bacterid -- carbamazepine -- drug‐induced hypersensitivity syndrome -- human herpesvirus 6 -- skeletal muscle; Dermatology -- Periodicals; Dermatology -- Japan -- Periodicals; Skin -- Diseases -- Periodicals; 616.5005
• DOI: 10.1111/1346-8138.12028
• Languages: English
• ISSNs: 0385-2407

Abstract

Abstract: Drug‐induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe reaction usually associated with maculopapular eruptions and systemic involvement. Here we report the first case, to our knowledge, of DIHS/DRESS due to carbamazepine with acute generalized pustular bacterid‐like (AGPB‐like) eruptions and skeletal muscle involvement. Reviewing our case and the published work, we discuss pustular‐type DIHS/DRESS which, in most cases, involves acute generalized exanthematous pustulosis (AGEP)‐like skin eruptions in response to carbamazepine. Pustular eruptions may appear in relatively few cases of DIHS/DRESS, in particular, when the causative drug is carbamazepine and, even in cases of intractable pustular bacterid‐like eruptions, a reaction to a drug should be suspected. Skeletal muscle involvement may be associated with DIHS/DRESS as one of its systemic manifestations.