Sulfamic Acid‐Catalyzed One‐Pot Synthesis of a New Series of Biologically Relevant Indole‐Uracil Molecular Hybrids in Water at Room Temperature. Issue 12 (26th March 2018)

• Record Type: Journal Article
• Authors: Brahmachari, Goutam; Begam, Sanchari; Nurjamal, Khondekar
• Is Part Of: ChemistrySelect. Volume 3:Issue 12(2018)
• Page Start: 3400
• Page End: 3405
• Publication Date: 2018-03-26
• Subjects: Environmentally benign -- Room temperature -- Sulfamic acid -- Uracil-indole molecular hybrids -- Water medium; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201800488
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: A simple, straightforward, and highly efficient three‐component one‐pot synthesis of a new series of biologically‐interesting diverse and functionalized 5‐((1 H ‐indol‐3‐yl)(aryl)methyl)‐6‐aminopyrimidine‐2, 4(1 H, 3 H )‐dione derivatives has been elaborated based on molecular hybridization approach. The target molecules have been rationalized via tandem reaction of 6‐aminouracils, substituted aromatic aldehydes and indoles in the presence of sulfamic acid as a low‐cost and eco‐friendly organocatalyst in water at room temperature. High atom‐economy, energy‐efficiency, use of water as reaction medium, good to excellent yields, metal‐free synthesis, eco‐friendliness, and operational simplicity are some of the important features of this newly developed protocol. Abstract : Sulfamic acid is superb ! Water‐mediated, metal‐free, and room temperature‐based synthesis of a new series of biologically relevant diverse and functionalized indole‐uracil molecular hybrids with high atom‐economy and operational simplicity has been accomplished under the influence of sulfamic acid as a low‐cost and eco‐friendly organocatalyst.