Vitamin C in sepsis. Issue 1 (February 2018)

• Record Type: Journal Article
• Authors: Kuhn, Sven-Olaf; Meissner, Konrad; Mayes, Lena M.; Bartels, Karsten
• Is Part Of: Current opinion in anaesthesiology. Volume 31:Issue 1(2018:Feb.)
• Publication Date: 2018-02
• Subjects: ascorbic acid -- resuscitation -- sepsis -- supplements -- vitamin C; Anesthesiology -- Periodicals; Anesthesiology -- Indexes; Anesthesiology -- Periodicals; Review Literature -- Indexes; Review Literature -- Periodicals; Anesthesiology; Periodicals; 617.9605
• DOI: 10.1097/ACO.0000000000000549
• Languages: English
• ISSNs: 0952-7907

Abstract

Abstract : Purpose of review: This narrative review summarizes recent insights into the role of vitamin C in sepsis. Recent findings: Septic shock remains a major source of morbidity and mortality in critically ill patients. Although many nutritional supplements have previously been tested unsuccessfully, vitamins are still being explored as a therapeutic option in septic patients. In particular, vitamin C-containing regimens as adjunctive therapy in sepsis have received much attention. Summary: In-vitro evidence supports a critical role for vitamin C in cellular mechanisms relevant to the pathophysiology of sepsis. However, whether this justifies therapeutic use of vitamin C in septic patients remains uncertain.