Primary Ovarian Solid Pseudopapillary Neoplasm With CTNNB1 c.98C>G (p.S33C) Point Mutation. (March 2018)

• Record Type: Journal Article
• Authors: Singh, Kamaljeet; Patel, Nimesh; Patil, Pallavi; Paquette, Cherie; Mathews, Cara A.; Lawrence, W. Dwayne
• Is Part Of: International journal of gynecological pathology. Volume 37:Number 2(2018)
• Publication Date: 2018-03
• Subjects: Ovary -- Solid papillary neoplasm -- Catenin -- Point mutation -- Extrapancreatic; Gynecologic pathology -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.10705
• DOI: 10.1097/PGP.0000000000000396
• Languages: English
• ISSNs: 0277-1691

Abstract

Abstract : Ovary is one of the extrapancreatic sites of origin of solid pseudopapillary neoplasm (SPN). Only 9 cases of primary ovarian SPN, 1 with CTNNB1 mutation similar to pancreatic SPN, have been reported in the English literature. We describe the second case of ovarian SPN with confirmed CTNNB1 mutation. A 49-year-old postmenopausal woman presented with a 4.5 cm right ovarian mass. Ovarian mass showed histologic and immunohistochemical features of pancreatic SPN. The ovarian surface was intact and uninvolved. Ki-67 index was low (1%–5%). DNA sequencing of CTNNB1 exon 3 revealed c.98C>G (p.S33C), a well-characterized activating mutation. Our case adds to the growing body of evidence that primary ovarian SPN are phenotypically and genotypically similar to pancreatic SPN.