A Case of Familial Mediterranean Fever Having Intermittent Leukopenia. Issue 2 (March 2018)

• Record Type: Journal Article
• Authors: Beyitler, Ilke; Kavukcu, Salih
• Is Part Of: Journal of pediatric hematology/oncology. Volume 40:Issue 2(2018)
• Publication Date: 2018-03
• Subjects: familial mediterranean fever -- leukopenia -- neutropenia -- amyloidosis; Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; 618.9215
• DOI: 10.1097/MPH.0000000000001055
• Languages: English
• ISSNs: 1077-4114

Abstract

Abstract : Familial Mediterranean fever (FMF) is a genetically inherited autoinflammatory disorder characterized by inflammatory attacks and may result in amyloidosis as a severe complication. Elevation of acute phase reactants, including leukocytosis, is seen during attack periods. Here we describe a 13-year-old female patient with a very rare clinical presentation of FMF, who would experience FMF attacks when she did not regularly take her colchicine. During these attacks she had leukopenia and neutropenia instead of leukocytosis. The leukocyte count returned to normal when she continued the medication and avoided attacks. Ethnicity and clinical signs are important in leukopenic patientsand should be investigated for FMF to avoid unnecessary procedures and complications.