Fibroadenoma-like Lesion of the Vagina: A Description of 2 Cases of a Previously Unreported Entity. (March 2018)

• Record Type: Journal Article
• Authors: Moore, Michelle; McKenna, Michael; Mandavilli, Srinivas; McCluggage, W. Glenn
• Is Part Of: International journal of gynecological pathology. Volume 37:Number 2(2018)
• Publication Date: 2018-03
• Subjects: Vagina -- Fibroadenoma -- Immunohistochemistry; Gynecologic pathology -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.10705
• DOI: 10.1097/PGP.0000000000000399
• Languages: English
• ISSNs: 0277-1691

Abstract

Abstract : We report 2 cases of a previously undescribed vaginal lesion, which we term "fibroadenoma-like lesion of the vagina" because of the close morphologic resemblance to breast fibroadenoma. Both lesions arose in the upper vagina and exhibited a biphasic appearance with benign epithelial and stromal elements. The glandular epithelium comprised a double layer of luminal and basal cells with focal squamous differentiation in 1 case. The stromal component was fibroblastic and morphologically bland for the most part, although occasional atypical symplastic-like cells were present in 1 case. Both lesions exhibited a similar immunophenotype with the luminal and basal glandular epithelium expressing PAX8 and GATA3 while estrogen receptor and progesterone receptor were largely negative. The basal cell layer was p63 and CK5/6 positive. We discuss the possible origin and histogenesis of this rare lesion which we believe to be benign based on the morphologic features and uneventful 5 years follow-up in 1 case.