The Association of Recently Diagnosed Diabetes and Long-term Diabetes With Survival in Pancreatic Cancer Patients: A Pooled Analysis. Issue 3 (March 2018)

• Record Type: Journal Article
• Authors: Jeon, Christie Y.; Li, Donghui; Cleary, Sean; Stolzenberg-Solomon, Rachael; Bosetti, Cristina; La Vecchia, Carlo; Porta, Miquel; Toriola, Adetunji T.; Hung, Rayjean J.; Kurtz, Robert C.; Olson, Sara H.
• Is Part Of: Pancreas. Volume 47:Issue 3(2018)
• Publication Date: 2018-03
• Subjects: diabetes -- pancreatic cancer -- pooled analysis -- survival; Pancreas -- Diseases -- Periodicals; Pancreas -- Periodicals; Neuroendocrine tumors -- Periodicals; 616.37005
• DOI: 10.1097/MPA.0000000000000989
• Languages: English
• ISSNs: 0885-3177

Abstract

Abstract : Objectives: It is unclear whether long-standing diabetes or new-onset pancreatogenic diabetes contributes to poor prognosis in patients with pancreatic ductal adenocarcinoma (PDAC). Methods: We investigated the influence of diabetes diagnosed shortly before PDAC and long-term diabetes on overall survival in 2792 PDAC patients who had participated in 3 PDAC case-control studies in the Pancreatic Cancer Case-Control Consortium. There were 300 patients with long-term diabetes of more than 3 years' duration (11%) and 418 patients with recently diagnosed diabetes of 3-year duration or less (15%). We performed Cox regression to determine the association of long-term diabetes and recently diagnosed diabetes with overall survival, adjusting for study site, age, sex, race, stage of disease, surgery, chemotherapy, smoking history, and body mass index at diagnosis. Results: In the overall population, neither long-term diabetes (hazard ratio [HR], 1.10; 95% confidence interval [CI], 0.97–1.26) nor recently diagnosed diabetes (HR, 1.06; 95% CI, 0.94–1.18) was associated with shorter survival. When stratified by stage of disease, long-term diabetes was associated with 42% increase in rate of death in persons with resectable PDAC (HR, 1.42; 95% CI, 1.13–1.78), whereas it was not associated with survival in PDAC patients with more advanced disease. Conclusion: Long-term diabetes was associated with increased rate of death in patients with resectable PDAC. Abstract : Supplemental digital content is available in the text.