Platelet-Derived Microvesicles: A Potential Therapy for Trauma-Induced Coagulopathy. Issue 3 (March 2018)

• Record Type: Journal Article
• Authors: Lopez, Ernesto; Srivastava, Amit K.; Pati, Shibani; Holcomb, John B.; Wade, Charles E.
• Is Part Of: Shock. Volume 49:Issue 3(2018)
• Publication Date: 2018-03
• Subjects: Coagulopathy -- extracellular vesicles -- microparticles -- therapy -- transfusions -- trauma; Shock -- Periodicals; Shock -- Periodicals; Choc (Pathologie) -- Périodiques; Shock; Periodicals; 616.0475
• DOI: 10.1097/SHK.0000000000000974
• Languages: English
• ISSNs: 1073-2322

Abstract

Abstract : ABSTRACT: Trauma patients are often affected by a hypocoagulable condition referred to as trauma-induced coagulopathy (TIC) for which few therapeutic options exist. One available treatment is fresh platelets transfusion, although it is not efficacious enough and has a number of limitations. Therefore, we reviewed the literature to propose an alternative therapy based on platelet-derived microvesicles (PMVs), which are cellular fragments surrounded by extracellular membrane and filled with cytoplasmic content. This concept is supported by a large number of studies in which the hypercoagulable role of PMVs has been demonstrated and associated with thrombosis-related conditions. The purpose of this review is to summarize what is currently known about PMVs and discuss whether a transfusion of isolated human PMVs could be used as a therapy for TIC.