Association between obesity and sleep disorders in postmenopausal women. Issue 2 (February 2018)

• Record Type: Journal Article
• Authors: Naufel, Maria Fernanda; Frange, Cristina; Andersen, Monica Levy; Girão, Manoel João Batista Castello; Tufik, Sergio; Beraldi Ribeiro, Eliane; Hachul, Helena
• Is Part Of: Menopause. Volume 25:Issue 2(2018)
• Publication Date: 2018-02
• Subjects: Insomnia -- Menopause -- Obesity -- Postmenopause -- Sleep; Menopause -- Periodicals; 618.175005
• DOI: 10.1097/GME.0000000000000962
• Languages: English
• ISSNs: 1072-3714

Abstract

Abstract: Objective: To investigate the relationship between obesity and sleep architecture in postmenopausal women. Methods: One hundred seven postmenopausal women from the Ambulatory of Integrative Treatment for Female Sleep Disorders were invited by telephone to participate in this study. Fifty-three completed the study. We included women aged 50 to 70 years, and excluded women on hormone therapy or missing data. The study consisted of two meetings, including a full-night polysomnography. Menopause status was confirmed by amenorrhea for at least 1 year. Anthropometric measurements included: body mass, height, body mass index (BMI), waist circumference, hip circumference, waist-to-hip ratio (WHR), and neck circumference. Participants were allocated into two groups according to BMI: nonobese group (BMI <30 kg/m 2 ) and obese group (BMI ≥30 kg/m 2 ). Results: The obese group had significantly ( P < 0.01) increased values of BMI, neck circumference, waist circumference, and hip circumference. WHR was similar between the groups ( P = 0.77). Obese participants had significantly increased values of respiratory disturbance index (16.4 vs 9.3 n°/h) and apnea-hypopnea index (14.2 vs 5.6 n°/h). Rapid eye movement sleep latency was positively correlated to body mass ( r = P < 0.01), BMI ( P < 0.01), and hip circumference ( P = 0.01). WHR was negatively correlated to sleep efficiency ( P = 0.03). The linear regression model showed that BMI ( P < 0.01) and WHR ( P < 0.01) were positive predictors of rapid eye movement sleep latency. Conclusion: In postmenopausal women, high BMI and abdominal obesity are sources of sleep disturbances, decreasing deep sleep, and sleep efficiency, while increasing the risk of obstructive sleep apnea.