Complete Recovery After Acute Zonisamide Overdose in an Adolescent Female. Issue 2 (February 2018)

• Record Type: Journal Article
• Authors: McStay, Charlayne; Pierce, Richard; Riley, Carley
• Is Part Of: Pediatric emergency care. Volume 34:Issue 2(2018)
• Publication Date: 2018-02
• Subjects: zonisamide -- overdose -- ingestion; Pediatric emergencies -- Periodicals; 618.92002505
• DOI: 10.1097/PEC.0000000000000854
• Languages: English
• ISSNs: 0749-5161

Abstract

Abstract : Abstract: Zonisamide is a sulfonamide drug used primarily for the treatment of partial seizures in adults. We describe the case of a 15-year-old woman with a mood disorder who survived without complications after ingestion of an estimated 7.5 g of zonisamide. To the best of our knowledge, there are 4 case reports of individuals with intentional ingestion of more than 4 g of zonisamide as a single agent. Our patient developed coma and hypotension 4 hours after ingestion and was treated with a catecholamine infusion, endotracheal intubation, and mechanical ventilation. She had mild electrocardiographic abnormalities and fully recovered after 4 days. This report contributes to the understanding of acute zonisamide poisoning.