A double branched photosensitive prodrug: synthesis and characterization of light triggered drug release. Issue 8 (24th February 2016)

• Record Type: Journal Article
• Authors: Liu, Wei; Liang, Li; Lo, Pik Kwan; Gou, Xiao Jun; Sun, Xiao Hua
• Is Part Of: Tetrahedron letters. Volume 57:Issue 8(2016)
• Page Start: 959
• Page End: 963
• Publication Date: 2016-02-24
• Subjects: Photoremovable protecting group -- Drug release -- o-Nitrobenzyl -- Prodrug -- Chlorambucil; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.01.064
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: A novel o NB based, double branched photosensitive prodrug1, and a biphenyl counterpart2 were designed and synthesized. Their photo-triggered drug release properties were studied by HPLC and UV–vis spectra. The isobestic points in UV–vis spectra of prodrug1 indicated that homogeneous photolysis reaction happened upon xenon-based light irradiation. HPLC analysis confirmed that (antitumor) chlorambucil was released quickly accompanied with photobyproducts. Prodrug1 has a half-time ( t 1/2 ) of 12.4 min, indicated a good sensitivity towards the light irradiation, making it a promising candidate for applications where UV light is limited.