The application of ion mobility mass spectrometry to metabolomics. (February 2018)

• Record Type: Journal Article
• Authors: Zhang, Xing; Quinn, Kevin; Cruickshank-Quinn, Charmion; Reisdorph, Richard; Reisdorph, Nichole
• Is Part Of: Current opinion in chemical biology. Volume 42(2018)
• Page Start: 60
• Page End: 66
• Publication Date: 2018-02
• Subjects: Bioorganic chemistry -- Periodicals; Biology -- Periodicals; Biochemistry -- Periodicals; Clinical biochemistry -- Periodicals; Biochemistry -- Periodicals; Chimie bio-organique -- Périodiques; Biologie -- Périodiques; 572.05
• DOI: 10.1016/j.cbpa.2017.11.001
• Languages: English
• ISSNs: 1367-5931

Abstract

Highlights: Advantages/limitations of IMMS for metabolomics are reviewed. IMMS can offer improved compound identification and metabolome coverage. Commercial IMMS systems and various front-end separation techniques are discussed. IMMS has potential for high throughput analysis of a range of metabolite classes. Recent applications utilizing IMMS include clinical metabolomics and lipidomics. Abstract : Mass spectrometry-based metabolomics is being increasingly utilized in various research fields including investigating human diseases, nutrition, industrial applications, and plant/natural products studies. Although new analytical approaches have enhanced the performance of metabolomic analyses, significant challenges associated with throughput, metabolome coverage, and compound identification still exist. Ion mobility mass spectrometry offers great potential for improving throughput and depth of coverage in metabolomics experiments. For example, multi-dimensional, structural resolution offered by ion mobility enables improved identification of metabolites and chemical classes. This mini-review discusses the advantages, recent developments and limitations of using ion mobility mass spectrometry as part of a metabolomics workflow.