Effect of single-dose intravenous dexamethasone on subjective voice quality after thyroidectomy: A meta-analysis. Issue 36 (September 2018)

• Record Type: Journal Article
• Authors: Kim, Jong Seung; Kwon, Sam Hyun; Lee, So Eun; Lee, Eun Jung; Lee, Min Hee
• Other Names: Thakur. Jagdeep section editor.
• Is Part Of: Medicine. Volume 97:Issue 36(2018)
• Publication Date: 2018-09
• Subjects: dexamethasone -- thyroidectomy -- voice; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000011832
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Background: Corticosteroids are widely used to treat voice change after thyroidectomy. In this study, we evaluated the effect of a single dose of intravenous dexamethasone after thyroidectomy using a metaanalysis. Methods: Relevant studies were identified by searching the following databases: Medline, Embase, and Cochrane through February 2017. We followed PRISMA guidelines. The following search terms were used: "thyroidectomy, " "voice, " "steroid." Random-effects models were used to estimate standardized mean differences (SMDs) and 95% confidence intervals. Results: Our search yielded one retrospective cohort study involving 122 thyroidectomy patients and 3 randomized controlled studies involving 242 thyroidectomy patients. The pooled SMD for voice quality after thyroidectomy was −0.80 ( P < .05). Subgroup analysis showed significant voice quality change 1 day after administration of dexamethasone. Conclusions: Single-dose intravenous dexamethasone after thyroidectomy significantly improves subjective voice quality on day 1. The effect was not different significantly after day 1. Level of evidence: Level 2a.