Autophagy in Cardiovascular Aging. Issue 7 (14th September 2018)

• Record Type: Journal Article
• Authors: Abdellatif, Mahmoud; Sedej, Simon; Carmona-Gutierrez, Didac; Madeo, Frank; Kroemer, Guido
• Is Part Of: Circulation research. Volume 123:Issue 7(2018)
• Publication Date: 2018-09-14
• Subjects: autophagy -- caloric restriction -- cardiovascular diseases -- heart -- longevity; Cardiovascular system -- Periodicals; Blood -- Circulation -- Periodicals; Blood Circulation; Cardiovascular System; Vascular Diseases; Sang -- Circulation -- Périodiques; Appareil cardiovasculaire -- Périodiques; 612.1
• DOI: 10.1161/CIRCRESAHA.118.312208
• Languages: English
• ISSNs: 0009-7330

Abstract

Abstract : Cardiovascular diseases are the most prominent maladies in aging societies. Indeed, aging promotes the structural and functional declines of both the heart and the blood circulation system. In this review, we revise the contribution of known longevity pathways to cardiovascular health and delineate the possibilities to interfere with them. In particular, we evaluate autophagy, the intracellular catabolic recycling system associated with life- and health-span extension. We present genetic models, pharmacological interventions, and dietary strategies that block, reduce, or enhance autophagy upon age-related cardiovascular deterioration. Caloric restriction or caloric restriction mimetics like metformin, spermidine, and rapamycin (all of which trigger autophagy) are among the most promising cardioprotective interventions during aging. We conclude that autophagy is a fundamental process to ensure cardiac and vascular health during aging and outline its putative therapeutic importance.