ANRIL polymorphism rs4977574 is associated with increased risk of coronary artery disease in Asian populations: A meta-analysis of 12, 005 subjects. Issue 39 (September 2018)

• Record Type: Journal Article
• Authors: Xu, Bing; Fang, Zhen; He, Shenghu; Wang, Junhong; Yang, Xiangjun
• Other Names: Roever. Leonardo section editor.
• Is Part Of: Medicine. Volume 97:Issue 39(2018)
• Publication Date: 2018-09
• Subjects: ANRIL -- coronary artery disease -- myocardial infarction -- polymorphism -- rs4977574; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000012641
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Background: Several studies have shown that ANRIL polymorphism may be associated with the risk of coronary artery disease (CAD). However, these studies do not provide a clear consensus in Asian population. Thus, this meta-analysis was aimed to evaluate the relationship between the common variant rs4977574 in ANRIL and CAD risk in Asian population. Methods: We conducted a systematic literature search of PubMed, Embase and the Cochrane Library and 2 Chinese databases. A total of 12, 005 subjects from 6 independent studies were included. The pooled odds ratio (OR) and their corresponding 95% confidence intervals (CIs) were used to assess the association between rs4977574 and CAD using random effects model. Results: A significant association was observed between rs4977574 and CAD risk under the allelic (OR: 1.18, 95% CI: 1.04–1.34, P = .010), recessive (OR: 1.27, 95% CI: 1.01–1.60, P = .04), dominant (OR: 1.28, 95% CI: 1.13–1.44, P = .002), homozygous (OR: 1.46, 95% CI: 1.15–1.86, P = .002), and heterozygous model (OR: 1.17, 95% CI: 1.07–1.28, P = .0004), especially in the Chinese subgroup and the myocardial infarction (MI) subgroup ( P < .05). Conclusion: The ANRIL polymorphism rs4977574 is associated with CAD risk in Asian population. The rs4977574 with G allele may confer to a higher risk of CAD, especially MI. Abstract : Supplemental Digital Content is available in the text