Coinfection with cryptococcus and aspergillus in an immunocompetent adult: A case report. Issue 39 (September 2018)

• Record Type: Journal Article
• Authors: Wang, Qi; Wang, Zhaoyong; Hao, Yuqiu; Li, Wei; Xin, Tong; Chen, Mo; Gao, Peng
• Other Names: NA. section editor.
• Is Part Of: Medicine. Volume 97:Issue 39(2018)
• Publication Date: 2018-09
• Subjects: aspergillosis -- aspergillus -- cryptococcosis -- Cryptococcus neoformans -- healthy host; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000012612
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Rationale: Aspergillus and Cryptococcus exposure can cause serious secondary infections in human lungs, especially in immunocompromised patients or in conjunction with a chronic disease caused by low disease resistance. Primary invasive fungal infections are clinically rare; therefore, coexistence of 2 fungi at an infection site is uncommon. This paper reports a case of healthy male who was diagnosed with both Cryptococcus neoformans and Aspergillus infections. Patient concerns: A healthy 33-year-old male office worker was admitted to the Second Hospital of Jilin University for hemoptysis. A chest computed tomography (CT) scan showed a cavity, which was formed by the thick dorsal wall of the lower left lobe with an irregular inner wall and burr changes around the lesion. Intervention: After 1.0 week of antibiotic and antituberculosis treatment, the hemoptysis symptoms remained. A resection of the left lower lobe was performed. Diagnoses: The postoperative pathological reports indicated the presence of both Aspergillus and Cryptococcus . The 2 fungal lesions were separate but within the same location. Outcomes: After treatment, the patient no longer had hemoptysis. Lessons: The current study indicated that fungi can infect not only immunocompromised patients but also healthy people, and that there can be 2 separate fungal infections at the same infection site.