Preparation, characterization, and evaluation of amino acid modified magnetic nanoparticles: drug delivery and MRI contrast agent applications. (26th November 2018)

• Record Type: Journal Article
• Authors: Nosrati, Hamed; Salehiabar, Marziyeh; Bagheri, Zahra; Rashidzadeh, Hamid; Davaran, Soodabeh; Danafar, Hossein
• Is Part Of: Pharmaceutical development and technology. Volume 23:Number 10(2018)
• Page Start: 1156
• Page End: 1167
• Publication Date: 2018-11-26
• Subjects: Magnetic nanoparticles -- hemolysis -- MRI -- theranostic -- drug delivery -- chrysin; Drug delivery systems -- Periodicals; Pharmaceutical technology -- Periodicals; Drugs -- Administration -- Research -- Periodicals; Drug Delivery Systems -- Periodicals; Pharmaceutical Preparations -- Periodicals; Technology, Pharmaceutical -- Periodicals; 615
• DOI: 10.1080/10837450.2018.1536995
• Languages: English
• ISSNs: 1083-7450

Abstract

Abstract: This study is a report about the synthesis iron oxide magnetic nanoparticles (IONPs) which modified with positive and negative charged amino acids (AAs).l -Arginine (Arg) andl -aspartic acid (Asp) which have of guanidinium and carboxylic acid groups, respectively, were selected for this study. After loading chrysin in amino acids modified iron oxide magnetic nanoparticles (F@AAs@Chrysin NPs), it was characterized by XRD, TGA, FTIR, VSM, and TEM techniques. Finally, MTT assays on HFF-2 and HEK-293 cell lines were performed for determination of biocompatibility of AA coated IONPs. The results show that, the ζ-potential and average size of F@Arg@chrysin NPs and F@Asp@chrysin NPs were to −3.87, −2.12 mV, 18.75 ± 2.40 (mean ± SD ( n = 50)) nm, and 19.86 ± 2.22 (mean ± SD ( n = 48)) nm, respectively. Also, the results indicated that these F@AAs@Chrysin NPs were appropriate for delivery of chrysin. Furthermore, the phantom MRI studies showed the IONPs can be used as contrast agent for the revealing of tumor. Graphical Abstract: