Glucocorticoid signaling and osteoarthritis. (15th January 2019)

• Record Type: Journal Article
• Authors: Savvidou, Olga; Milonaki, Mandy; Goumenos, Stavros; Flevas, Dimitrios; Papagelopoulos, Panayiotis; Moutsatsou, Paraskevi
• Is Part Of: Molecular and cellular endocrinology. Volume 480(2019)
• Page Start: 153
• Page End: 166
• Publication Date: 2019-01-15
• Subjects: Osteoarthritis -- Glucocorticoid -- Signaling -- Receptor -- Inflammation -- Homeostasis; OA Osteoarthritis -- GC Glucocorticoid -- HPA Hypothalamic-pituitary-adrenal -- GR Glucocorticoid Receptor -- NSAID Non-Steroidal Anti-Inflammatory Drug -- IA Intraarticular -- NR3C1 nuclear receptor subfamily 3 group C member 1 -- GRE Glucocorticoid Response Element -- nGRE Negative Glucocorticoid Response Element -- STAT5A Signal Transducer and Activator of Transcription 5A -- CREB cAMP Response Element-Binding protein -- AP-1 Activator Protein 1 -- NF-κB Nuclear Factor kappa-light-chain-enhancer of activated B cells -- mGR Membrane-bound Glucocorticoid Receptor -- SEGRAM Selective Glucocorticoid receptor Agonist and Modulator -- ECM Extracellular Matrix -- DAMPs Damage Associated Molecular Patterns -- TNF Tumor Necrosis Factor -- CCL2 C-C motif Chemokine Ligand 2 -- CXCL1 C-X-C motif Chemokine Ligand 1 -- CXCL8 C-X-C motif Chemokine Ligand 8 -- MMP Matrix Metallopeptidase -- CCL5 C-C motif Chemokine Ligand 5 -- NO Nitric Oxide -- iNOS inducible Nitric Oxide Synthase -- TIMP Tissue Inhibitor of Metalloproteinase -- ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 -- ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 -- HIF Hypoxia-Inducible Factor -- MAPK Mitogen-activated Protein Kinase -- ERK Extracellular signal–Regulated Kinase -- JNK c-Jun N-terminal Kinase -- IGF (Insulin Growth Factor) -- TGF-β Transforming Growth Factor beta -- NGF Nerve Growth Factor -- VEGF Vascular Endothelial Growth Factor -- BMP Bone Morphogenetic Protein -- DUSP1 Dual Specificity Phosphatase 1 -- GILZ Glucocorticoid-Induced Leucine Zipper -- ANXA1 Annexin A1 -- SCRG1 Stimulator of Chondrogenesis 1 -- LCN2 Lipocalin 2 -- RA rheumatoid arthritis -- 11β-HSD1 11β-hydroxysteroid dehydrogenase type 1 -- PGE2 Prostaglandin E2; Endocrinology -- Periodicals; Molecular biology -- Periodicals; Cytology -- Periodicals; Endocrinology -- Periodicals; Hormones -- Periodicals; Endocrinologie -- Périodiques; Cytology; Endocrinology; Molecular biology; Periodicals; 573.4
• DOI: 10.1016/j.mce.2018.11.001
• Languages: English
• ISSNs: 0303-7207

Abstract

Abstract: Glucocorticoids are steroid hormones synthesized and released by the adrenal cortex. Their main function is to maintain cell homeostasis through a variety of signaling pathways, responding to changes in an organism's environment or developmental status. Mimicking the actions of natural glucocorticoids, synthetic glucocorticoids have been recruited to treat many diseases that implicate glucocorticoid receptor signaling such as osteoarthritis. In osteoarthritis, synthetic glucocorticoids aim to alleviate inflammation and pain. The variation of patients' response and the possibility of complications associated with their long-term use have led to a need for a better understanding of glucocorticoid receptor signaling in osteoarthritis. In this review, we performed a literature search in the molecular pathways that link the osteoarthritic joint to the glucocorticoid receptor signaling. We hope that this information will advance research in the field and propose new molecular targets for the development of more optimized therapies for osteoarthritis. Highlights: Glucocorticoids regulate cell homeostasis through the multifaceted actions of the glucocorticoid receptor. The value of glucocorticoid treatment in osteoarthritis is constantly being questioned. Glucocorticoid signaling affects joint metabolism and its effects are context-dependent.