Association of interleukin 3 (IL-3) polymorphisms with schizophrenia in Han Chinese population. (25th September 2015)

• Record Type: Journal Article
• Authors: Liu, Zichao; Huang, Liang; Wang, Dingkang; Wu, Lichuan
• Is Part Of: Neuroscience letters. Volume 605(2015)
• Page Start: 12
• Page End: 17
• Publication Date: 2015-09-25
• Subjects: Interleukin 3 -- Single nucleotide polymorphism -- Schizophrenia -- Chinese population; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2015.08.014
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: We analyzed six single nucleotide polymorphisms in IL-3 with schizophrenia in Chinese population. We used two independent samples, including a total of 901 schizophrenia patients and 1417 healthy controls. The IL-3 has been reported conferring risk of schizophrenia in Irish populations, but is not significant in our Han Chinese samples. Abstract: Schizophrenia has been observed to be associated with various abnormalities in multiple cytokines. Recent genetic analyses showed that the interleukin 3 (IL-3) gene and its receptors are significantly associated with schizophrenia, especially in Irish populations. To examine the associations of the Irish-risk single nucleotide polymorphisms (SNPs, e.g., rs3916441) in the IL-3 gene with schizophrenia in Chinese population, we utilized two independent samples from Southwestern China, including a total 901 schizophrenia patients and 1417 healthy controls. However, no statistically significant differences were observed in allelic or genotypic frequencies of the tested 6 SNPs in IL-3 between cases and controls in any sample. Therefore, the results of our analyses were not able to confirm the association of IL-3 SNPs with schizophrenia. The absence of the IL-3's association in Chinese population suggest a potential genetic heterogeneity in the susceptibility of schizophrenia on this locus and also demonstrate the difficulties in replicating associations of schizophrenia across different ethnic populations.