Comparative study of the efficacy and safety between blonanserin and risperidone for the treatment of schizophrenia in Chinese patients: A double-blind, parallel-group multicenter randomized trial. (October 2015)

• Record Type: Journal Article
• Authors: Li, Huafang; Yao, Chen; Shi, Jianguo; Yang, Fude; Qi, Shuguang; Wang, Lili; Zhang, Honggeng; Li, Jie; Wang, Chuanyue; Wang, Chuansheng; Liu, Cui; Li, Lehua; Wang, Qiang; Li, Keqing; Luo, Xiaoyan; Gu, Niufan
• Is Part Of: Journal of psychiatric research. Volume 69(2015:Oct.)
• Page Start: 102
• Page End: 109
• Publication Date: 2015-10
• Subjects: Antipsychotic agents -- Blonanserin -- Randomized controlled trial -- Risperidone -- Schizophrenia; Psychiatry -- Periodicals; Mental Disorders -- Periodicals; Maladies mentales -- Périodiques; Psychiatry; Electronic journals; Periodicals; 616.89005
• DOI: 10.1016/j.jpsychires.2015.07.015
• Languages: English
• ISSNs: 0022-3956

Abstract

Abstract: This randomized, double-blind study compared the efficacy and safety of blonanserin and risperidone to treat Chinese schizophrenia patients aged ≥18 and < 65 years. Patients with Positive and Negative Syndrome Scale (PANSS) total scores ≥70 and ≤ 120 were randomized to receive blonanserin or risperidone using a gradual dose-titration method (blonanserin tablets: 8–24 mg/day; risperidone tablets: 2–6 mg/day), twice daily. Treatment populations consisted of 128 blonanserin-treated patients and 133 risperidone-treated patients. Intention-to-treat analysis was performed using the last observation carried forward method. Reductions of PANSS total scores by blonanserin and risperidone treatment were −30.59 and −33.56, respectively. Risperidone treatment was associated with elevated levels of serum prolactin (67.16% risperidone versus 52.31% blonanserin) and cardiac-related abnormalities (22.39% risperidone versus 12.31% blonanserin), and blonanserin patients were more prone to extrapyramidal side effects (48.46% blonanserin versus 29.10% risperidone). In conclusion, blonanserin was as effective as risperidone for the treatment of Chinese patients with schizophrenia. The overall safety profiles of these drugs are comparable, although blonanserin was associated with a higher incidence of EPS and risperidone was associated with a higher incidence of prolactin elevation and weight gain. Thus, blonanserin is useful for the treatment of Chinese schizophrenia patients. Graphical abstract: Highlights: We compared blonanserin and risperidone for treating Chinese schizophrenia patients. Patients aged 18–65 years with a PANSS total score of 70–120 were randomized. Based on a PANSS total score change, blonanserin was as effective as risperidone. Blonanserin was well tolerated and TEAEs were similar for both groups. Blonanserin is a useful novel treatment option for Chinese schizophrenia patients.