Autologous hematopoietic stem cell transplantation in elderly patients (≥ 70 years) with non-Hodgkin's lymphoma: A French Society of Bone Marrow Transplantation and Cellular Therapy retrospective study. Issue 5 (September 2015)

• Record Type: Journal Article
• Authors: Hermet, E.; Cabrespine, A.; Guièze, R.; Garnier, A.; Tempescul, A.; Lenain, P.; Bouabdallah, R.; Vilque, J.P.; Frayfer, J.; Bordessoule, D.; Sibon, D.; Janvier, M.; Caillot, D.; Biron, P.; Legros, L.; Choufi, B.; Drenou, B.; Gorin, N.C.; Bilger, K.; Tamburini, J.; Soussain, C.; Brechignac, S.; Bay, J.O.
• Is Part Of: Journal of geriatric oncology. Volume 6:Issue 5(2015)
• Page Start: 346
• Page End: 352
• Publication Date: 2015-09
• Subjects: Non-Hodgkin lymphoma -- High dose chemotherapy -- Autologous stem cell transplantation -- Elderly patients -- Treatment related mortality; Geriatric oncology -- Periodicals; Neoplasms -- Periodicals; Aged -- Periodicals; Geriatric oncology; Electronic journals; Periodicals; 618.976994005
• DOI: 10.1016/j.jgo.2015.04.005
• Languages: English
• ISSNs: 1879-4068

Abstract

Abstract: Introduction: Limited data is available on the feasibility of high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (AHSCT) in elderly patients over 70 years of age with non-Hodgkin's lymphoma (NHL). Materials and Methods: In the setting of the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC) group, we retrospectively analyzed 81 consecutive patients with NHL over 70 years of age who received AHSCT. Results: The median age at AHSCT was 72.3 years [70–80]. Patients' were diagnosed with diffuse large B-cell lymphoma (n = 40), follicular lymphoma (n = 16), mantle cell lymphoma (n = 15), T-cell lymphoma (n = 5), and other (n = 5). Hematopoietic Cell Transplantation Comorbidity Index (HCT-CI) was 0 in 73% of patients. Main conditionings were BEAM (Carmustine-Etoposide-Cytarabine-Melphalan, n = 61) and melphalan alone (n = 14). Median delays to reach 0.5 × 10 9 /L neutrophils and 20 × 10 9 /L platelets were of 12 [9–76] days and 12 [0–143] days, respectively. One hundred day and one year cumulative incidence of NRM was 5.4% and 8.5%, respectively. The main cause of death remains relapse. Conclusion: In conclusion, this study revealed that AHSCT seemed to be acceptable in patients over 70 years of age with NHL. Patient age is not a limiting factor if clinical condition is adequate.