Six New Polyhydroxysteroidal Glycosides, Anthenosides S1 – S6, from the Starfish Anthenea sibogae. Issue 3 (2nd March 2018)

• Record Type: Journal Article
• Authors: Kicha, Alla A.; Ha, Dinh T.; Ivanchina, Natalia V.; Malyarenko, Timofey V.; Kalinovsky, Anatoly I.; Dmitrenok, Pavel S.; Ermakova, Svetlana P.; Malyarenko, Olesya S.; Hung, Nguyen A.; Thuy, Tran T. T.; Long, Pham Q.
• Is Part Of: Chemistry & biodiversity. Volume 15:Issue 3(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-03-02
• Subjects: Anthenea sibogae -- starfish -- polyhydroxysteroids -- glycosides -- clonogenic assay; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.201700553
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract : Six new polyhydroxysteroidal glycosides, anthenosidesS1 – S6 (1 – 6 ), along with a mixture of two previously known related glycosides, 7 and8, were isolated from the methanolic extract of the starfish Anthenea sibogae . The structures of1 – 6 were established by NMR and HR‐ESI‐MS techniques as well as by chemical transformations. All new compounds have a 5 α ‐cholest‐8(14)‐ene‐3 α, 6 β, 7 β, 16 α ‐tetrahydroxysteroidal nucleus and differ from majority of starfish glycosides in positions of carbohydrate moieties at C(7) and C(16) (1 – 4, 6 ) or only at C(16) (5 ). The 4‐ O ‐methyl‐ β ‐d ‐glucopyranose residue (2 ) and Δ 24 ‐cholestane side chain (3 ) have not been found earlier in the starfish steroidal glycosides. The mixture of7 and8 slightly inhibited the proliferation of human breast cancer T‐47D cells and decreased the colony size in the colony formation assay. Abstract :