Cover Feature: Synthetic Cancer‐Targeting Innate Immune Stimulators Give Insights into Avidity Effects (ChemBioChem 5/2018). (16th February 2018)

• Record Type: Journal Article
• Authors: Conibear, Anne C.; Pötgens, André J. G.; Thewes, Karine; Altdorf, Claudia; Hilzendeger, Clarissa; Becker, Christian F. W.
• Is Part Of: Chembiochem. Volume 19:Number 5(2018)
• Page Start: 421
• Page End: 421
• Publication Date: 2018-02-16
• Subjects: antitumor agents -- chemoselective ligation -- immune stimulators -- multivalent drugs -- peptides; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201800076
• Languages: English
• ISSNs: 1439-4227

Abstract

Abstract : The cover feature picture shows three men on a climbing wall representing molecules binding to a cell with one, two or four binding moieties. To explore avidity effects on immune stimulation and cancer cell binding, chemoselective ligations were used to assemble molecules that mimic the functions of antibodies with various numbers and combinations of immune‐stimulating and cancer‐targeting peptides. More information can be found in the full paper by A. C. Conibear, C. F. W. Becker et al. onpage 459 in Issue 5, 2018 (DOI:10.1002/cbic.201700522 ).