Serum amyloid A1 (SAA1) protein in human colostrum. Issue 3 (31st January 2018)

• Record Type: Journal Article
• Authors: Sack, George H.; Zachara, Natasha; Rosenblum, Nadine; Talbot, C. Conover; Kreimer, Simion; Cole, Robert; McDonald, Thomas L.
• Is Part Of: FEBS open bio. Volume 8:Issue 3(2018)
• Page Start: 435
• Page End: 441
• Publication Date: 2018-01-31
• Subjects: acute‐phase -- amyloid -- colostrum -- serum amyloid A; Molecular biology -- Periodicals; Cytology -- Periodicals; Life sciences -- Periodicals; Biological Science Disciplines -- Periodicals; Molecular Biology -- Periodicals; Cell Biology -- Periodicals; Cytology; Life sciences; Molecular biology; Periodicals; 572.805
• DOI: 10.1002/2211-5463.12383
• Languages: English
• ISSNs: 2211-5463

Abstract

Abstract : Proteins of the serum amyloid A (SAA) family have been remarkably conserved in evolution. Their biologic function(s) are not fully defined but they are likely to be a part of primordial host defense. We have detected a ∼ 12‐kDa protein reacting with antibodies against serum amyloid A (SAA) in human colostrum by western blotting. Mass spectrometry identified the reactive species as SAA1, previously identified as a prominent member of the acute‐phase response in serum. Our finding SAA1 in human colostrum contrasts with bovine, caprine and ovine colostrum where a species corresponding to putative SAA3 is uniformly present. SAA1 protein in human colostrum presumably contributes to neonatal protection. Abstract : The prominent human acute‐phase reactant SAA1 protein has been detected in human colostrum, contrasting bovine, caprine and ovine colostrum where SAA3 protein has been found. A single nucleotide insertion in the human SAA3 gene leads to premature termination. Control of SAA1 expression in human mammary epithelium is novel and presumably provides a survival benefit to the newborn.