The potential of the microbiota to influence vaccine responses. Issue 2 (28th December 2017)

• Record Type: Journal Article
• Authors: Lynn, David J.; Pulendran, Bali
• Other Names: Mansell Ash guestEditor.; Triccas Jamie guestEditor.; Tonkin Chris guestEditor.; Moseley Greg guestEditor.
• Is Part Of: Journal of leukocyte biology. Volume 103:Issue 2(2018)
• Page Start: 225
• Page End: 231
• Publication Date: 2017-12-28
• Subjects: antibiotics -- antibody -- B cell -- T cell -- short‐chain fatty acids; Leucocytes -- Periodicals; Reticulo-endothelial system -- Periodicals; 571.96
• DOI: 10.1189/jlb.5MR0617-216R
• Languages: English
• ISSNs: 0741-5400

Abstract

Abstract: After clean water, vaccines are the primary public health intervention providing protection against serious infectious diseases. Antigen‐specific antibody‐mediated responses play a critical role in the protection conferred by vaccination; however these responses are highly variable among individuals. In addition, vaccine immunogenicity is frequently impaired in developing world populations, for reasons that are poorly understood. Although the factors that are associated with interindividual variation in vaccine responses are likely manifold, emerging evidence from mouse models and studies in human populations now suggests that the gut microbiome plays a key role in shaping systemic immune responses to both orally and parenterally administered vaccines. Herein, we review the evidence to date that the microbiota can influence vaccine responses and discuss the potential mechanisms through which these effects may be mediated. In addition, we highlight the gaps in this evidence and suggest future directions for research.