A Metal–Organic Framework with Exceptional Activity for C−H Bond Amination. Issue 2 (13th December 2017)

• Record Type: Journal Article
• Authors: Wang, Le; Agnew, Douglas W.; Yu, Xiao; Figueroa, Joshua S.; Cohen, Seth M.
• Is Part Of: Angewandte Chemie international edition. Volume 57:Issue 2(2018)
• Page Start: 511
• Page End: 515
• Publication Date: 2017-12-13
• Subjects: amination -- heterogeneous catalysis -- manganese -- metal–organic frameworks -- nitrenes; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201709420
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: The development of catalysts capable of fast, robust C−H bond amination under mild conditions is an unrealized goal despite substantial progress in the field of C−H activation in recent years. A Mn‐based metal–organic framework (CPF‐5) is described that promotes the direct amination of C−H bonds with exceptional activity. CPF‐5 is capable of functionalizing C−H bonds in an intermolecular fashion with unrivaled catalytic stability producing >10 5 turnovers. Abstract : A Mn‐based MOF (metal–organic framework) with a unique active site catalyzes C−H amination under mild conditions. Importantly, the catalyst displays an exceptional and unprecedented TON of >120 000, which is about 4 orders of magnitude greater than any other state‐of‐the‐art C−H amination catalysts.