Time-resolved measurement of bubble cavitation by using power Doppler ultrasound image. (15th March 2017)

• Record Type: Journal Article
• Authors: Koda, Ren; Izumi, Yosuke; Nagai, Hayato; Yamakoshi, Yoshiki
• Is Part Of: Japanese journal of applied physics. Volume 56:Number 4(2017)
• Publication Date: 2017-03-15
• Subjects: Physics -- Periodicals; 621.05
• DOI: 10.7567/JJAP.56.047201
• Languages: English
• ISSNs: 0021-4922

Abstract

Abstract: In this study, a novel measurement method for a secondary ultrasound wave irradiated by microbubble cavitation is proposed. High-intensity ultrasound (h-US, 1.0–1.5 MPa), which produces bubble cavitation, is irradiated with a fixed time delay after introducing imaging US, whose frequency is different from that of the h-US. The bubble cavitation signal (BCS) is detected by the signal-processing unit of an ultrasound power Doppler imaging instrument. By this method, both a spatially resolved bubble image (S-image) and the temporal transition of the BCS (T-image) are monitored simultaneously. A feature of the method is that the BCS is observed in situ with sub-µs time resolution. The accuracy of the method is evaluated and it is found that the maximum deviation of the amplitude of the simulated BCS is 4.80%. This method is applied to measure the BCS of ultrasound contrast agent microbubbles. As a result, the dependence of the inherent temporal transition of the BCS on the sound pressure of the h-US (0.6–1.2 MPa) is observed.