A facile synthesis and antibacterial activity of novel pyrrolo[3, 4-b]quinolin-2(3H)-yl)benzamides. Issue 4 (2nd October 2017)

• Record Type: Journal Article
• Authors: Hosseyni Largani, Tahere; Imanzadeh, Gholamhassan; Zahri, Saber; Noroozi Pesyan, Nader; Şahin, Ertan
• Is Part Of: Green chemistry letters and reviews. Volume 10:Issue 4(2017)
• Page Start: 387
• Page End: 392
• Publication Date: 2017-10-02
• Subjects: Pyrrolo[3, 4-b]quinolin-2(3H)-yl)benzamides -- molecular hybridization -- antibiotic resistance -- minimum inhibitory concentration -- eco-friendly approach; Green chemistry -- Periodicals; 540
• DOI: 10.1080/17518253.2017.1380233
• Languages: English
• ISSNs: 1751-8253

Abstract

ABSTRACT: A new series of pyrrolo[3, 4-b]quinolin-2(3H)-yl)benzamides were designed based on molecular hybridization approach and synthesized by reaction of benzohydrazide derivatives with 9-phenylfuro[3, 4-b]quinoline-1, 3-diones in the presence of an Et3 N catalyst. Simple reaction, excellent yield, simple separation process and eco-friendly approach by minimizing the chemical waste renders this protocol particularly attractive. The series9a–g was evaluated for in vitro antibacterial activity against (+ve bacteria) Staphylococcus aureus ATCC 25923 and Enterococcus faecalis ATCC 29212, (−ve bacterium) Escherichia coli ATCC 25922. In vitro minimum inhibitory concentration (MIC) evaluations showed that the compound9a was effective against E. coli (MIC: 0.25 mg/mL) S. aureus (MIC: 0.25 mg/mL) and E. faecalis (MIC: 0.5 mg/mL). GRAPHICAL ABSTRACT: