Genetics Influence Neurocognitive Performance at Baseline but Not Concussion History in Collegiate Student-Athletes. Issue 2 (March 2018)

• Record Type: Journal Article
• Authors: Cochrane, Graham D.; Sundman, Mark H.; Hall, Eric E.; Kostek, Matthew C.; Patel, Kirtida; Barnes, Kenneth P.; Ketcham, Caroline J.
• Is Part Of: Clinical journal of sport medicine. Volume 28:Issue 2(2018)
• Publication Date: 2018-03
• Subjects: concussions -- mild traumatic brain injury -- genetics -- neurocognitive performance -- cognitive function; Sports medicine -- Periodicals; 617.1027
• DOI: 10.1097/JSM.0000000000000443
• Languages: English
• ISSNs: 1050-642X

Abstract

Abstract : Objective: This study investigates 4 single-nucleotide polymorphisms [Apolipoprotein E (APOE), APOE promoter, catechol-O-methyl transferase (COMT), and dopamine D2 receptor] that have been implicated in concussion susceptibility and/or cognitive ability in collegiate student-athletes. Design: Cross-sectional study. Setting: Neuroscience laboratory at Elon University. Participants: Two hundred fifty division I collegiate student-athletes (66 women, 184 men) from various sports. Intervention: All participants completed Immediate Postconcussion Assessment and Cognitive Testing (ImPACT) testing at baseline concussion testing and had a buccal swab taken for DNA for genotyping. Main Outcome Measures: Self-reported history of concussions and neurocognitive performance were taken from ImPACT. Results: Individuals carrying an ε4 allele in their APOE gene had a significantly slower reaction time ( P = 0.001). Individuals homozygous for the Val allele of the COMT gene showed significantly worse impulse control scores ( P = 0.014). None of the genotypes were able to predict self-reported concussion history in collegiate student-athletes. Conclusions: These results indicate that certain genotypes may influence performance on cognitive testing at baseline and that the APOE genotypes may not influence concussion susceptibility as suggested by past studies.