Microwave‐Assisted Synthesis of Imidazoquinazoline for Chemosensing of Pb2+ and Fe3+ and Living Cell Application. Issue 4 (30th January 2018)

• Record Type: Journal Article
• Authors: Iniya, Murugan; Vidya, Balasubramanian; Anand, Thangaraj; Sivaraman, Gandhi; Jeyanthi, Dharmaraj; Krishnaveni, Karuppiah; Chellappa, Duraisamy
• Is Part Of: ChemistrySelect. Volume 3:Issue 4(2018)
• Page Start: 1282
• Page End: 1288
• Publication Date: 2018-01-30
• Subjects: Chemosensor -- Density functional theory calculations -- Imaging -- Iron -- Lead -- Ratiometry; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201702860
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: An efficient dual‐responsive fluorescent probe based on imidazoquinazoline has been synthesised using microwave‐assisted solvent‐free condition. Its sensing behaviour towards Pb 2+ and Fe 3+ has been investigated separately through fluorescence, absorbance and visual fluorescence colour changes in different solvent systems. Interestingly, the binding event triggers selective "turn‐on" response to Pb 2+ and ratiometric response to Fe 3+ against other commonly coexistent metal ions. The observed experimental data has been rationalized in terms of theoretical calculations. The living cell imaging experiment demonstrated the practical value of the sensor in mapping intracellular Fe 3+ and Pb 2+ distributions in biological systems. Abstract : A simple, efficient and practical methodology for the synthesis of imidazoquinazoline using microwave‐assisted reaction strategy is developed. The molecular system acts as bifunctional sensor for the detection of Pb 2+ and Fe 3+ with different fluorescence response in different solvent condition. More interestingly, probe displays ratiometric response to Fe 3+ in aqueous acetonitrile solution. The probe features excellent selectivity, high sensitivity, good reversibility and low detection limit.