Fibroblast growth factor 23–secreting pancreaticobiliary malignancy. Issue 1 (February 2018)

• Record Type: Journal Article
• Authors: Barta, Valerie; Lalkiya, Neel; Phan, Huy; Miller, Ilene; Sachdeva, Mala
• Is Part Of: Journal of onco-nephrology. Volume 2:Issue 1(2018)
• Page Start: 21
• Page End: 23
• Publication Date: 2018-02
• Subjects: Hypophosphatemia -- oncogenic osteomalacia -- phosphaturia -- tumor-induced osteomalacia -- fibroblast growth factor 23; Nephrology -- Periodicals; Kidneys -- Cancer -- Periodicals; Kidneys -- Tumors -- Periodicals; 616.61
• DOI: 10.1177/2399369318776177
• Languages: English
• ISSNs: 2399-3693

Abstract

Malignancy-related tumor-induced osteomalacia is a rare but important entity. We report the first case of oncogenic renal phosphate wasting in the setting of a pancreaticobiliary malignancy. Our patient presented with refractory hypophosphatemia. Workup revealed high fibroblast growth factor 23 levels as well as a new pancreaticobiliary mass. All other causes of hypophosphatemia were ruled out. With tumor-induced osteomalacia, an accurate diagnosis and location of the offending tumor is essential for appropriate management and treatment.