Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions. Issue 36 (20th August 2015)

• Record Type: Journal Article
• Authors: Burke, Benjamin P.; Baghdadi, Neazar; Kownacka, Alicja E.; Nigam, Shubhanchi; Clemente, Gonçalo S.; Al-Yassiry, Mustafa M.; Domarkas, Juozas; Lorch, Mark; Pickles, Martin; Gibbs, Peter; Tripier, Raphaël; Cawthorne, Christopher; Archibald, Stephen J.
• Is Part Of: Nanoscale. Volume 7:Issue 36(2015)
• Page Start: 14889
• Page End: 14896
• Publication Date: 2015-08-20
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c5nr02753e
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Silica coated iron oxide nanorods can be radiolabelled with gallium-68 without the need for a chelator to give in vivo stable multimodal PET/MR imaging agents. Abstract : The commercial availability of combined magnetic resonance imaging (MRI)/positron emission tomography (PET) scanners for clinical use has increased demand for easily prepared agents which offer signal or contrast in both modalities. Herein we describe a new class of silica coated iron–oxide nanorods (NRs) coated with polyethylene glycol (PEG) and/or a tetraazamacrocyclic chelator (DO3A). Studies of the coated NRs validate their composition and confirm their properties as in vivo T 2 MRI contrast agents. Radiolabelling studies with the positron emitting radioisotope gallium-68 ( t 1/2 = 68 min) demonstrate that, in the presence of the silica coating, the macrocyclic chelator was not required for preparation of highly stable radiometal-NR constructs. In vivo PET-CT and MR imaging studies show the expected high liver uptake of gallium-68 radiolabelled nanorods with no significant release of gallium-68 metal ions, validating our innovation to provide a novel simple method for labelling of iron oxide NRs with a radiometal in the absence of a chelating unit that can be used for high sensitivity liver imaging.