Quantitative assessment of erector spinae muscles in patients with Mycobacterium avium complex lung disease. (December 2018)

• Record Type: Journal Article
• Authors: Asakura, Takanori; Yamada, Yoshitake; Suzuki, Shoji; Namkoong, Ho; Okamori, Satoshi; Kusumoto, Tatsuya; Niijima, Yuki; Ozaki, Akihiko; Hashimoto, Masahiro; Yagi, Kazuma; Kamata, Hirofumi; Funatsu, Yohei; Ishii, Makoto; Jinzaki, Masahiro; Betsuyaku, Tomoko; Hasegawa, Naoki
• Is Part Of: Respiratory medicine. Volume 145(2018)
• Page Start: 66
• Page End: 72
• Publication Date: 2018-12
• Subjects: Nontuberculous mycobacteria (NTM) -- Mycobacterium avium complex (MAC) -- Respiratory function tests -- Computed tomography -- St. George's respiratory questionnaire (SGRQ) -- The 36-Item short-form health survey (SF-36); 6MWD 6-min walk distance -- ATS/IDSA American Thoracic Society/Infectious Disease Society of America -- BMI body mass index -- CCI Charlson Comorbidity Index -- CI confidence interval -- COPD chronic obstructive pulmonary disease -- CRP C-reactive protein -- CSA cross-sectional area -- CT computed tomography -- ESMs erector spinae muscles -- ESMCSA cross-sectional area of the erector spinae muscles -- FEV1 forced expiratory volume in 1 s -- FC fibrocavitary -- FVC forced vital capacity -- HRQL health-related quality -- HRs hazard ratios -- HU Hounsfield unit -- IQR interquartile range -- MAC Mycobacterium avium complex -- MAC-LD Mycobacterium avium complex lung disease -- MCS mental component summary -- MDCT multidetector-row computed tomography -- NB nodular/bronchiectatic -- NTM nontuberculous mycobacterial -- PCS physical component summary -- PFTs pulmonary function tests -- RCS role/social component summary -- SD standard derivation -- SF-36 36-Item Short-Form Health Survey -- SGRQ St George's Respiratory Questionnaire; Chest -- Diseases -- Periodicals; Chest -- Diseases -- Great Britain -- Periodicals; Respiratory organs -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Appareil respiratoire -- Maladies -- Périodiques; Thorax -- Maladies -- Périodiques; Appareil respiratoire -- Maladies -- Traitement -- Périodiques; Electronic journals; 616.2
• DOI: 10.1016/j.rmed.2018.10.023
• Languages: English
• ISSNs: 0954-6111

Abstract

Abstract: Background and objective: No reports exist regarding skeletal muscle involvement in patients with Mycobacterium avium complex lung disease (MAC-LD). The cross-sectional area of the erector spinae muscles (ESMCSA ) reflects physical activity and can be assessed by computed tomography (CT). We investigated the relationship between ESMCSA and physiological parameters and prognosis in MAC-LD patients. Material and methods: In this prospective observational study, the ESMCSA was measured on single-slice axial CT images. MAC-LD patients and sex- and age-matched controls (non-MAC-LD participants) were evaluated. We evaluated the relationship between the ESMCSA and physiological parameters and prognosis. Results: A total of 260 patients (209 female; median age, 69 years; 190 with nodular/bronchiectatic disease; 74 with cavitary lesions) were enrolled. The ESMCSA was not different between MAC-LD patients and controls. In MAC-LD patients, the ESMCSA was significantly associated with age, body mass index (BMI), pulmonary function, CT severity, and health-related quality of life (HRQL). Multivariate Cox proportional hazards analyses revealed that an ESMCSA < −1 standard derivation (hazards ratio [HR], 2.76; P = 0.047) was significantly associated with all-cause mortality, along with BMI < 18.5 kg/m 2 (HR, 3.67; P = 0.02) and presence of cavitary lesions (HR, 5.84; P = 0.001). However, the ESMCSA was not significantly associated with all-cause mortality when current treatment status, % predicted functional vital capacity, and forced expiratory volume in 1 s were added to the analyses. Conclusions: Although the prognostic impact was limited, ESMCSA was significantly associated with HRQL and prognostic physiological parameters, such as BMI and pulmonary function. Highlights: We investigated the clinical involvement of erector spinae muscles (ESMs) in MAC-LD. The cross-sectional area of ESMs (ESMCSA ) is associated with pulmonary function, severity of MAC-LD lesions, and HRQL. ESMCSA was associated with all-cause mortality along with BMI and cavitary lesions.