Simultaneous or sequential administration of botulinum neurotoxin E does not reduce the duration of paralysis caused by botulinum neurotoxin A in rat EDL muscle. (18th March 2011)

• Record Type: Journal Article
• Authors: Adler, Michael; Deshpande, Sharad S.; Apland, James P.
• Is Part Of: Botulinum journal. Volume 1:Number 4(2010)
• Page Start: 442
• Page End: 456
• Publication Date: 2011-03-18
• Subjects: botulinum neurotoxin -- BoNT&amp -- #47 -- A -- BoNT&amp -- #47 -- E -- persistence -- rats -- EDL muscle -- paralysis -- recovery -- twitch tension -- tetanic tension -- BoNT -- botulism -- SNAP-25 -- nerve terminals -- nerve ends; Botulinum toxin -- Periodicals; Clostridium botulinum -- Periodicals; Drug development -- Periodicals; 615.9529364
• Languages: English
• ISSNs: 1754-7318

Abstract

Exposure to botulinum neurotoxin serotype A (BoNT/A) or serotype E (BoNT/E) results in muscle paralysis owing to cleavage of the SNARE protein SNAP-25 between residues 197-198 or 180-181, respectively. Although SNAP-25 is the substrate for both serotypes, the duration of paralysis is considerably longer for muscles exposed to BoNT/A. This study was designed to determine whether paralysis times were determined by differences in the half-lives of the truncated SNAP-25 fragments or by differences in the persistence of the respective BoNT light chain (LC) within the nerve terminals.