A pilot trial of onabotulinumtoxinA for the treatment of cervicothoracic myofascial pain. (8th August 2011)

• Record Type: Journal Article
• Authors: Davis, Thomas L.; Fang, John Y.; Gill, Chandler E.; Charles, P. David
• Is Part Of: Botulinum journal. Volume 2:Number 1(2011)
• Page Start: 6
• Page End: 15
• Publication Date: 2011-08-08
• Subjects: CMPS -- cervicothoracic myofascial pain syndrome -- BOTOX safety -- cervical dystonia -- botulinum toxin -- cervical myofascial pain syndrome -- BOTOX efficacy -- onabotulinumtoxinA -- pain relief; Botulinum toxin -- Periodicals; Clostridium botulinum -- Periodicals; Drug development -- Periodicals; 615.9529364
• Languages: English
• ISSNs: 1754-7318

Abstract

This placebo-controlled crossover trial investigate the safety and efficacy of onabotulinumtoxinA (BOTOX, Allergan, Inc.) for the treatment of cervical myofascial pain syndrome (CMPS). A group of subjects with Cervical Dystonia (CD) served as additional controls. A change in diary pain score from baseline to week 3 in placebo vs. onabotulinumtoxinA was the primary outcome measure. Both CMPS and CD subjects showed a trend towards significant pain relief from onabotulinumtoxinA. This suggests that the study was underpowered and that a larger sample size would be necessary in future trials of onabotulinumtoxinA for CMPS.