Assessment of the osteoblastic cell response to a zinc glass reinforced hydroxyapatite composite (Zn-GRHA). (10th August 2009)

• Record Type: Journal Article
• Authors: Sooraj Hussain, N.; Gomes, P.S.; Fernandes, M.H.; Lopes, M.A.; , J.D. Santos
• Is Part Of: International journal of nano and biomaterials. Volume 2:Number 1/2/3/4/5(2009)
• Page Start: 100
• Page End: 109
• Publication Date: 2009-08-10
• Subjects: zinc glass-reinforced hydroxyapatite -- Zn-GRHA composites -- cell proliferation -- osteoblastic cell response -- bioceramics -- biomaterials -- graft materials; Nanostructured materials -- Periodicals; Nanotechnology -- Periodicals; Biomedical materials -- Periodicals; 620.505
• Languages: English
• ISSNs: 1752-8933

Abstract

Hydroxyapatite (HA), Ca10(PO4)6(OH)2 and tricalcium phosphate (TCP) bioceramics have been used as graft materials. However, optimal biological performance has not been established yet and zinc, being a biosafe, biocompatible element, could favour for specific osteoblastic cell response. Therefore, this paper investigates the preliminary results and potential impact of zinc glass reinforced hydroxyapatite (Zn-GRHA) on a human osteoblastic cell system. The biological behaviour of Zn-GRHA samples was assessed by confocal laser scanning microscopy, while material characterisation was performed by SEM-EDX and XRD analysis. Established cultures reported an increased proliferation and a confluent cell layer in some areas of the material surface at day two. Cells were spread all over the material surface and established multiple cell-to-cell interactions relying on prominent cytoplasmic processes. At day six, confluent cell layers were verified on the Zn-GRHA material's surface, reporting an improved biological response, compared to control (hydroxyapatite).