Maximising return on investment (ROI) for pharmaceutical production. (7th May 2012)

• Record Type: Journal Article
• Authors: Ibrahim, Sameh A.; Mostafa, Noha A.
• Is Part Of: International journal of manufacturing technology and management. Volume 24:Number 1-4(2011)
• Page Start: 167
• Page End: 181
• Publication Date: 2012-05-07
• Subjects: pharmaceuticals manufacturing -- process mapping -- simulation -- design of experiment -- DOE -- analysis of variance -- ANOVA; Manufacturing processes -- Periodicals; Manufacturing processes -- Automation -- Periodicals; Production management -- Periodicals; 670.427068
• Languages: English
• ISSNs: 1368-2148

Abstract

Production scheduling tools close the gap between ERP/MRP II tools and the plant floor. Simulation can be used to generate production schedules on an ongoing basis in a way that does not violate constraints related to the limited availability. In this paper, the process of tablet manufacturing in a pharmaceutical production plant is studied, first the full process is described and mapped, and then a process simulation is run. Based on the simulation results, statistical analysis is performed; the data is fitted by using regression analysis. Design of experiment (DOE) analysis is performed on the process to try many different combinations of resource levels automatically, and finally analysis of variance (ANOVA) is performed to select infeasible products that can be excluded from future production plans, this will have a positive effect on the return on investment for the organisation.